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The medicinal chemist's guide to solving ADMET challenges / (Record no. 7970)

MARC details
000 -LEADER
fixed length control field 05386cam a2200661Ii 4500
001 - CONTROL NUMBER
control field on1265408571
003 - CONTROL NUMBER IDENTIFIER
control field OCoLC
005 - DATE AND TIME OF LATEST TRANSACTION
control field 20241121072941.0
006 - FIXED-LENGTH DATA ELEMENTS--ADDITIONAL MATERIAL CHARACTERISTICS--GENERAL INFORMATION
fixed length control field m d
007 - PHYSICAL DESCRIPTION FIXED FIELD--GENERAL INFORMATION
fixed length control field cr cnu---unuuu
008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION
fixed length control field 210827s2021 enk o 001 0 eng d
040 ## - CATALOGING SOURCE
Original cataloging agency UKRSC
Language of cataloging eng
Description conventions rda
-- pn
Transcribing agency UKRSC
Modifying agency EBLCP
-- OCLCO
-- YDX
-- N$T
019 ## -
-- 1265085890
020 ## - INTERNATIONAL STANDARD BOOK NUMBER
International Standard Book Number 9781788016414
Qualifying information (electronic bk.)
020 ## - INTERNATIONAL STANDARD BOOK NUMBER
International Standard Book Number 1788016416
Qualifying information (electronic bk.)
020 ## - INTERNATIONAL STANDARD BOOK NUMBER
Cancelled/invalid ISBN 9781788012270
020 ## - INTERNATIONAL STANDARD BOOK NUMBER
Cancelled/invalid ISBN 1788012275
020 ## - INTERNATIONAL STANDARD BOOK NUMBER
International Standard Book Number 9781839160493
Qualifying information (electronic bk.)
020 ## - INTERNATIONAL STANDARD BOOK NUMBER
International Standard Book Number 1839160497
Qualifying information (electronic bk.)
035 ## - SYSTEM CONTROL NUMBER
System control number 3017769
-- (N$T)
035 ## - SYSTEM CONTROL NUMBER
System control number (OCoLC)1265408571
Canceled/invalid control number (OCoLC)1265085890
037 ## - SOURCE OF ACQUISITION
Stock number 5428:5277
Source of stock number/acquisition Royal Society of Chemistry
Note http://www.rsc.org/spr
050 #4 - LIBRARY OF CONGRESS CALL NUMBER
Classification number RM301.27
072 #7 - SUBJECT CATEGORY CODE
Subject category code SCI
Subject category code subdivision 013020
Source bisacsh
072 #7 - SUBJECT CATEGORY CODE
Subject category code SCI
Subject category code subdivision 007000
Source bisacsh
072 #7 - SUBJECT CATEGORY CODE
Subject category code PSB
Source bicssc
072 #7 - SUBJECT CATEGORY CODE
Subject category code PNN
Source bicssc
082 04 - DEWEY DECIMAL CLASSIFICATION NUMBER
Classification number 615.1901
Edition number 23
049 ## - LOCAL HOLDINGS (OCLC)
Holding library MAIN
245 04 - TITLE STATEMENT
Title The medicinal chemist's guide to solving ADMET challenges /
Statement of responsibility, etc edited by Patrick Schnider.
264 #1 -
-- Cambridge :
-- Royal Society of Chemistry,
-- 2021.
300 ## - PHYSICAL DESCRIPTION
Extent 1 online resource (1 volume)
336 ## -
-- text
-- txt
-- rdacontent
337 ## -
-- computer
-- c
-- rdamedia
338 ## -
-- online resource
-- cr
-- rdacarrier
490 1# - SERIES STATEMENT
Series statement RSC drug discovery
500 ## - GENERAL NOTE
General note Includes index.
588 0# -
-- Print version record.
505 0# - FORMATTED CONTENTS NOTE
Formatted contents note Intro -- Half Title -- Drug Discovery Series -- Title -- Copyright -- Preface -- Contents -- Chapter 1 Overview of Strategies for Solving ADMET Challenges -- 1.1 Introduction -- 1.2 Strategies by ADMET Properties -- 1.2.1 Tactics to Improve Solubility (Chapter 2) -- 1.2.2 Optimisation of Passive Permeability for Oral Absorption (Chapter 3) -- 1.2.3 Targeting Gastrointestinal Uptake Transporters (Chapter 4) -- 1.2.4 Drug Efflux Transporters: P-gp and BCRP (Chapter 5) -- 1.2.5 OATs and OCTs: The SLC22 Family of Organic Anion and Cation Transporters (Chapter 6)
505 8# - FORMATTED CONTENTS NOTE
Formatted contents note 1.2.6 OATPs: The SLCO Family of Organic Anion Transporting Polypeptide Transporters (Chapter 7) -- 1.2.7 Bile Salt Export Pump (BSEP) Inhibition (Chapter 8) -- 1.2.8 Cytochrome P450 Metabolism (Chapter 9) -- 1.2.9 Cytochrome P450 Induction (Chapter 10) -- 1.2.10 Strategies to Mitigate CYP450 Inhibition (Chapter 11) -- 1.2.11 Aldehyde and Xanthine Oxidase Metabolism (Chapter 12) -- 1.2.12 Glucuronidation (Chapter 13) -- 1.2.13 Sulfation (Chapter 14) -- 1.2.14 Reactive Metabolites (Chapter 15) -- 1.2.15 Genotoxicity (Chapter 16) -- 1.2.16 Drug-induced Photosensitivity (Chapter 17)
505 8# - FORMATTED CONTENTS NOTE
Formatted contents note 1.2.17 Drug-induced Phospholipidosis (Chapter 18) -- 1.2.18 Cardiac Ion Channel Inhibition (Chapter 19) -- 1.3 Strategies by Molecular Properties -- References -- Chapter 2 Tactics to Improve Solubility -- 2.1 Introduction: Relevance of Solubility for Drug Disposition -- 2.2 Definitions -- 2.2.1 Which Solubility Measure is Most Pertinent? -- 2.2.2 Solubility, Lipophilicity and pKa -- 2.2.3 General Solubility Equation (GSE) -- 2.2.4 Other Predictors: In Silico -- 2.3 Mitigation Strategies -- 2.3.1 Decrease Lipophilicity -- 2.3.2 Charge -- 2.3.3 Introduction of Polar Substituents
505 8# - FORMATTED CONTENTS NOTE
Formatted contents note 2.3.4 Replacement of Aromatic CH by N or O -- 2.3.5 Reduce Crystal Packing and Melting Point -- 2.3.6 Salt Forms -- 2.4 Examples of Mitigation Strategies -- 2.4.1 Changing Lipophilicity, Adding Polar Groups, Twists -- 2.4.2 Solid State Structure Manipulation to Reduce Melting Point -- 2.4.3 Modulating Intramolecular Interactions -- Reducing Melting Point -- 2.4.4 Reducing Planarity -- 2.4.5 Heterocyclic Switches, Reducing Aromaticity -- 2.4.6 Heterocyclic Switch -- 2.4.7 Disruption of Planarity -- 2.4.8 Simple Changes, Big Differences -- Crystal Packing and Effect of a Twist
505 8# - FORMATTED CONTENTS NOTE
Formatted contents note 2.4.9 Introducing Polar Clashes to Induce a Twist -- 2.4.10 Profound Effect of Methyl Substituents -- 2.4.11 Additions of a Solubilising Group -- 2.4.12 Salt Formation -- References -- Chapter 3 Optimisation of Passive Permeability for Oral Absorption -- 3.1 Introduction -- 3.1.1 Potential Mechanisms of Membrane Permeation -- 3.1.2 Strategies for Screening for Passive Permeability -- 3.1.3 Influence of Physicochemical Properties on Passive Permeability -- 3.1.4 Future Directions: Beyond Rule-of-five -- 3.1.5 Relevance -- 3.2 Mitigation Strategies -- 3.3 Examples of Mitigation Strategies
520 ## - SUMMARY, ETC.
Summary, etc The Medicinal Chemist's Guide to Solving ADMET Challenges presents state-of-the-art design strategies by a global group of experienced medicinal chemists and ADMET experts across academia and the pharmaceutical industry.
590 ## - LOCAL NOTE (RLIN)
Local note OCLC control number change
650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name as entry element Drugs
General subdivision Testing.
9 (RLIN) 17663
650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name as entry element Pharmaceutical chemistry.
9 (RLIN) 17664
655 #0 - INDEX TERM--GENRE/FORM
Genre/form data or focus term Electronic books.
9 (RLIN) 3907
655 #4 - INDEX TERM--GENRE/FORM
Genre/form data or focus term Electronic books.
9 (RLIN) 3907
700 1# - ADDED ENTRY--PERSONAL NAME
Personal name Schnider, Patrick,
Relator term editor.
9 (RLIN) 17665
776 08 - ADDITIONAL PHYSICAL FORM ENTRY
Display text Print version:
Title Medicinal chemist's guide to solving ADMET challenges.
Place, publisher, and date of publication Cambridge : Royal Society of Chemistry, 2020
International Standard Book Number 9781788012270
Record control number (OCoLC)1202969953
830 #0 - SERIES ADDED ENTRY--UNIFORM TITLE
Uniform title RSC drug discovery series.
9 (RLIN) 15873
856 40 - ELECTRONIC LOCATION AND ACCESS
Materials specified EBSCOhost
Uniform Resource Identifier <a href="https://search.ebscohost.com/login.aspx?direct=true&scope=site&db=nlebk&db=nlabk&AN=3017769">https://search.ebscohost.com/login.aspx?direct=true&scope=site&db=nlebk&db=nlabk&AN=3017769</a>
938 ## -
-- ProQuest Ebook Central
-- EBLB
-- EBL6709822
938 ## -
-- YBP Library Services
-- YANK
-- 302419817
938 ## -
-- EBSCOhost
-- EBSC
-- 3017769
994 ## -
-- 92
-- N$T

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