Includes bibliographical references and indexes.

PART I MOLECULAR AND CELLULAR BASIS OF HEMATOLOGY1. Anatomy and Physiology of the Gene2. Epigenomics in Hematology3. Genomic Approaches to Hematology4. Regulation of Gene Expression in Hematology5. Genome Editing6. Signaling Transduction and Metabolomics7. Protein Architecture: Relationship of Form and Function8. Pharmacogenomics and Hematologic DiseasesPART II CELLULAR BASIS OF HEMATOLOGY9. Hematopoietic Stem Cell Biology10. Mitochondria and Hematopoiesis11. Cytokines, Chemokines, Other Growth Factors, and Their Receptors12. Role of Chemokines in Leukocyte Trafficking13. Stem Cell Model of Hematologic Diseases14. Hematopoietic Microenvironment15. Cell Adhesion16. Current Biology of Stem Cell Homing and Mobilization: Dynamic Interactions Between Hematopoietic Stem and Progenitor Cells and Their Surrounding Bone Marrow Microenvironment17. Control of Cell Division18. Cell Death19. Aging and HematopoiesisPART III IMMUNOLOGIC BASIS OF HEMATOLOGY20. Dendritic Cell Biology21. Natural Killer Cell Immunity and Therapy22. B-Cell Development23. Complement and Immunoglobulin Biology Leading to Clinical Translation24. T-Cell Immunity25. Unmodified Ex Vivo Expanded T Cells26. Treatment of Hematologic Malignancies with Genetically Modified T CellsPART IV DISORDERS OF HEMATOPOIETIC CELL DEVELOPMENT27. Biology of Erythropoiesis, Erythroid Differentiation, and Maturation28. Granulocytopoiesis and Monocytopoiesis29. Thrombocytopoiesis30. Inherited Bone Marrow Failure Syndromes31. Aplastic Anemia32. Paroxysmal Nocturnal Hemoglobinuria33. Acquired Disorders of Red Cell, White Cell, and Platelet ProductionPART V RED BLOOD CELLS34. Pathobiology of the Human Erythrocyte and Its Hemoglobins35. Approach to Anemia in the Adult and Child36. Iron Homeostasis and Its Disorders37. Disorders of Iron Homeostasis: Iron Deficiency and Overload38. Anemia of Chronic Inflammation39. Heme Biosynthesis and Its Disorders: Porphyrias and Sideroblastic Anemias40. Megaloblastic Anemias41. Thalassemia Syndromes42. Pathobiology of Sickle Cell Disease43. Clinical Aspects of Sickle Cell Disease44. Hemoglobin Variants Associated with Hemolytic Anemia, Altered Oxygen Affinity, and Methemoglobinemias45. Red Blood Cell Enzymopathies46. Red Blood Cell Membrane Disorders47. Autoimmune Hemolytic Anemia48. Extrinsic Nonimmune Hemolytic AnemiasPART VI NON-MALIGNANT LEUKOCYTES49. Neutrophilic Leukocytosis, Neutropenia, Monocytosis, and Monocytopenia50. Lymphocytosis, Lymphocytopenia, Hypergammaglobulinemia, and Hypogammaglobulinemia51. Disorders of Phagocyte Function52. Congenital Disorders of Lymphocyte Function53. Pediatric and Adult Histiocytic Disorders54. Lysosomal Storage Diseases, Focusing on Gaucher Disease: Perspectives and Principles55. Epstein-Barr Virus and Associated Lymphoproliferative ConditionsPART VII HEMATOLOGIC MALIGNANCIES56. Progress in the Classification of Hematopoietic and Lymphoid Neoplasms: Clinical Implications57. Conventional and Molecular Cytogenomic Basis of Hematologic Malignancies58. Pharmacology and Molecular Mechanisms of Antineoplastic Agents for Hematologic Malignancies59. Pathobiology of Acute Myeloid Leukemia60. Clinical Manifestations and Treatment of Acute Myeloid Leukemia61. Myelodysplastic Syndromes62. Allogeneic Hematopoietic Stem Cell Transplantation for Acute Myeloid Leukemia and Myelodysplastic Syndrome in Adults63. Acute Myeloid Leukemia in Children64. Blastic Plasmacytoid Dendritic Cell Neoplasm65. Myelodysplastic Syndromes and Myeloproliferative Neoplasms in Children66. Pathobiology of Acute Lymphoblastic Leukemia67. Clinical Manifestations and Treatment of Childhood Acute Lymphoblastic Leukemia68. Acute Lymphoblastic Leukemia in Adults69. Chronic Myeloid Leukemia70. The Polycythemias71. Essential Thrombocythemia72. Primary Myelofibrosis and Chronic Neutrophilic Leukemia73. Myelodysplastic Syndrome/Myeloproliferative Neoplasm Overlap Syndromes74. Eosinophilia, Eosinophilic Neoplasms, and the Hypereosinophilic Syndromes75. Mast Cells and Mastocytosis76. Chronic Lymphocytic Leukemia77. Hairy Cell Leukemia78. The Pathologic Basis for the Classification of Non-Hodgkin and Hodgkin Lymphomas79. Origin of Hodgkin Lymphoma and Therapeutic Targets80. Hodgkin Lymphoma81. Origin of Non-Hodgkin Lymphoma and Therapeutic Targets82. Clinical Manifestations, Staging, and Treatment of Follicular Lymphoma83. Marginal Zone Lymphomas (Extranodal/MALT, Splenic, and Nodal)84. Diffuse Large B-Cell Lymphoma of the Central Nervous System85. High-Grade B-Cell Lymphomas86. Mantle Cell Lymphoma87. Virus-Associated Lymphoma88. Malignant Lymphomas in Childhood89. T-Cell Lymphomas90. Monoclonal Gammopathy of Undetermined Significance and Smoldering Multiple Myeloma91. Multiple Myeloma92. Waldenström Macroglobulinemia/Lymphoplasmacytic Lymphoma93. Immunoglobulin Light-Chain Amyloidosis (Primary Amyloidosis)PART VIII COMPREHENSIVE CARE OF PATIENTS WITH HEMATOLOGIC MALIGNANCIES94. Key Considerations for Managing Infections in the Compromised Host95. Principles of Radiation Therapy for Hematologic Disease96. Grading and Toxicity Management after Immune Effector Therapy97. Identification and Management of Checkpoint Inhibition Toxicity98. Psychosocial Aspects of Hematologic Disorders99. Pain Management and Antiemetic Therapy in Hematologic Disorders100. Palliative Care101. Therapy-related Late Effects of Hematologic MalignanciesPART IX TRANSPLANTATION AND OTHER CELL-BASED THERAPIES102. Practical Aspects of Hematopoietic Stem Cell Harvesting and Mobilization103. Graft Engineering and Cell Processing104. Principles of Cell-Based Genetic Therapies105. Indications, Outcomes, and Donor Selection for Allogeneic Hematopoietic Cell Transplantation for Hematologic Malignancies in Adults106. Unrelated Donor Hematopoietic Cell Transplantation107. Haploidentical Hematopoietic Stem Cell Transplantation108. Cord Blood Transplantation109. Graft-versus-Host Disease and Graft-versus- Leukemia Responses110. Supportive Care for the Transplant PatientPART X TRANSFUSION MEDICINE111. Human Blood Group Antigens and Antibodies112. Principles of Red Blood Cell Transfusion113. Clinical Considerations in Platelet Transfusion Therapy114. Human Leukocyte Antigen and Human Neutrophil Antigen Systems115. Principles of Plasma and Plasma Derivatives116. Hemapheresis117. Transfusion Reactions to Blood and Hematopoietic Stem Cell Therapy Products118. Transfusion-Transmitted Diseases119. Pediatric Transfusion Medicine120. Transfusion and Apheresis Support for Sickle Cell Disease PatientsPART XI HEMOSTASIS AND THROMBOSIS121. Overview of Hemostasis and Thrombosis122. Blood Vessels123. Megakaryocyte and Platelet Structure124. Molecular Basis of Platelet Function125. Molecular Basis of Blood Coagulation126. Evaluation of the Patient with Suspected Bleeding Disorders127. Laboratory Evaluation of Hemostatic and Thrombotic Disorders128. Acquired Disorders of Platelet Function129. Diseases of Platelet Number: Immune Thrombocytopenia, Neonatal Alloimmune Thrombocytopenia, and Posttransfusion Purpura130. Thrombocytopenia Caused by Hypersplenism, Platelet Destruction, or Surgery/Hemodilution131. Heparin-Induced Thrombocytopenia132. Thrombotic Thrombocytopenic Purpura and the Hemolytic Uremic Syndromes133. Structure, Biology, and Genetics of von Willebrand Factor134. Hemophilia A and B135. Rare Coagulation Factor Deficiencies136. Transfusion Therapy for Coagulation Factor Deficiencies137. Disseminated Intravascular Coagulation138. Hypercoagulable States139. Antiphospholipid Syndrome140. Venous Thromboembolism141. Prevention and Treatment of Venous Thromboembolism in Pregnancy142. Atherothrombosis143. Antithrombotic Drugs144. Stroke145. Acute Coronary Syndromes146. Peripheral Artery Disease147. Atrial Fibrillation148. Bleeding and Clotting Disorders in PediatricsPART XII CONSULTATIVE HEMATOLOGY149. Hematologic Changes in Pregnancy150. Hematologic Manifestations of End-Organ Failure151. Hematologic Manifestations of Solid Tumors152. Hematologic Manifestations of HIV/AIDS153. Hematologic Findings and Consequences of Novel Coronavirus (SARS-CoV-2) Infection154. Hematologic Aspects of Parasitic Diseases155. Hematologic Problems in the Surgical Patient: Bleeding and Thrombosis156. The Spleen and Its Disorders157. Aging and Hematologic Disorders158. Onco-cardiology: Focus on Cardiac Complications of Hematologic Treatments159. Resources for the Hematologist: Interpretive Comments and Selected Reference Values for Neonatal, Pediatric, and Adult Populations 2408.e1Chapter 159 can be found online at Elsevier eBooks for Practicing Clinicians