TY  - BOOK
AU  - Naiyer,Sarah
AU  - Bhat,Khalid Hussain
TI  - Transcriptomics and their importance
T2  - Cell Biology Research Progress Ser
SN  - 9798886972030
AV  - QH450.2 
U1  - 572.8/845 23/eng/20220831
PY  - 2022///]
CY  - New York
PB  - Nova Science Publishers
KW  - Genetic transcription
KW  - RNA editing
KW  - Transcription g�en�etique
KW  - ARN
KW  - �Edition
KW  - fast
KW  - Electronic books
N1  - Includes bibliographical references and index; Intro -- Contents -- Preface -- Acknowledgments -- List of Acronyms -- Part I. Introduction to Transcriptomics -- Chapter 1 -- The Nuts and Bolts in Transcriptomics -- Abstract -- 1. Introduction -- 2. History towards the Development of Transcriptomics -- 3. RNA Sequencing (RNA-Seq) -- 3.1. Advances in RNA-Seq -- 4. Computational Analysis of RNA Sequencing Data -- 4.1. Quality Control of Raw Data -- 4.2. Read Alignment and Transcript Assembly -- 4.3. Expression Quantification -- 4.4. Differential Expression Analysis -- Conclusion and Further Advancements in Transcriptomic Analysis; 4. Transcriptomics and Its Role in Understanding Cellular Function -- 4.1. Understanding Host Pathogen Interactions -- 4.2. Disease Profiling and Pathogenesis -- Conclusion -- References -- Part II. Understanding Cancer with Transcriptomics -- Chapter 3 -- Transcriptomics in Basic Cancer Biology -- Abstract -- 1. History of Gene Expression Techniques-Brief Introduction -- 2. RNA-Based Therapeutics -- 2.1. Tumor Heterogeneity and RNA-seq -- 2.2. Transcriptomics in Clinical Classifications of Cancer -- 2.3. Identification of Cancer Biomarkers for Early Detection; 3. Applications of RNA-Sequencing in Cancer Research -- 3.1. Cancer Variance and Adaptation -- 3.2. Cancer Drug Tolerance -- 3.3. Differential Gene Expression and Cancer Biomarkers -- 3.4. Cancer Immunotherapy -- 4. Application of Transcriptomics in Cancer Diagnostic -- 4.1. Breast Cancer -- 4.2. Colorectal Cancer -- 4.3. Lung Cancer -- 4.4. Prostate Cancer -- 4.5. Skin Cancer -- 4.6. Thyroid Cancer -- 5. Challenges and Limitations -- 5.1. Construction of Library -- 5.2. Cost vs Coverage -- 5.3. Bioinformatic Challenges -- Conclusion and Future Prospects -- References -- Chapter 4; Single-Cell Transcriptomics in Cancer Stem Cells (CSCs): Implications in Carcinogenesis and Drug Resistance -- Abstract -- 1. Introduction -- 2. Role of CSCs in Tumor Heterogeneity: Impact on Cancer Progression and Drug Resistance -- 3. Application of Single-Cell Transcriptomics in CSCs -- 4. Role of Single-Cell Transcriptomics in Personalised Therapy -- 5. Limitation of SCT in CSCs Driven Cancer -- Conclusion and Future Prospects -- References -- Chapter 5 -- Transcriptome: A Tool for Precision Oncology -- Abstract -- 1. Introduction
N2  - "Transcriptomics refers to the study of the transcriptome, which is the complete set of RNA transcripts produced by the genome of a specific cell. This book provides an overview of the information that the transcriptome provides and how developments in transcriptomics has transformed our understanding of cell biology. This book is comprised of three parts. Part I serves as an introduction to describe the development of transcriptomics as a technique and the way by which it has enhanced our knowledge and provided a better understanding of the basic biology of cellular function. Part II of the book is written to understand the milestones and contributions of transcriptomics in understanding the dynamics of cancer biology. Part III provides an insight on how transcriptomics is helping us to understand microbes and host-pathogen interaction including bioremediation"--
UR  - https://search.ebscohost.com/login.aspx?direct=true&scope=site&db=nlebk&db=nlabk&AN=3344239
ER  -