TY  - BOOK
AU  - Taskin,Eylem
AU  - Guven,Celal
AU  - Kaya,Salih Tun�c
TI  - HMGB1: functions, inhibitors and clinical significance 
T2  - Life sciences research and development
SN  - 8886974661
AV  - QH599 
U1  - 572.8/7 23/eng/20230118
PY  - 2022///]
CY  - New York
PB  - Nova Science Publishers
KW  - Chromatin
KW  - Miscellanea
KW  - Nervous system
KW  - Diseases
KW  - Pathophysiology
KW  - Chromatine
KW  - Miscellan�ees
KW  - Syst�eme nerveux
KW  - Maladies
N1  - Includes bibliographical references and index
N2  - "High mobility group box-1 (HMGB1) is one of the Damage-associated molecular patterns (DAMPs). HMGB1 plays plenty of role in both physiologic and pathophysiologic processes associated with its location, the receptor it binds to, and its redox form of its. Its functions are basically well known to have transcription factors, chemo-attractive effects, proinflammatory cytokine, neither chemokine nor cytokine effects, nor tissue repair function as well. This book provides an overview of the updated understanding of the dual role of HMGB1 in health and disease, such as cancer, myocardial ischemia/reperfusion injury, epilepsy, diabetes, multiple sclerosis, and neurodegenerative disease as well as hepatic steatosis and fatty liver disease been studied for years. That is why the modulation of HMGB1 might be a good candidate for the therapeutic of these diseases. Consequently, the present book comprises the role of HMGB1 in various pathologies and discusses its therapeutic potential in those pathologies"--
UR  - https://search.ebscohost.com/login.aspx?direct=true&scope=site&db=nlebk&db=nlabk&AN=3452120
ER  -