Includes bibliographical references and indexes.

SECTION 1: LIVER INHERITED, METABOLIC, AND DEVELOPMENTAL DISORDERS 4 Glycogen Storage Disease, HepaticJoseph Misdraji, MD, Lisa Yerian, MD, and Grace E. Kim, MD10 TyrosinemiaJoseph Misdraji, MD12 Niemann-Pick DiseaseJoseph Misdraji, MD14 Gaucher DiseaseJoseph Misdraji, MD16 Neonatal HemochromatosisJoseph Misdraji, MD18 Porphyrin Metabolism DisordersMaria Westerhoff, MD and Joseph Misdraji, MD24 Dubin-Johnson SyndromeJoseph Misdraji, MD and Sanjay Kakar, MD26 Gilbert DiseaseJoseph Misdraji, MD and Sanjay Kakar, MD28 Progressive Familial Intrahepatic CholestasisJoseph Misdraji, MD36 Cystic Fibrosis, HepaticJoseph Misdraji, MD40 Hereditary HemochromatosisJoseph Misdraji, MD and Laura W. Lamps, MD44 Wilson DiseaseJoseph Misdraji, MD and Laura W. Lamps, MD50 Alpha-1-Antitrypsin DeficiencyNicole C. Panarelli, MD, Kari D. Caradine, MD, and LauraW. Lamps, MD54 Congenital Hepatic FibrosisRomil Saxena, MBBS, MD, FRCPath (UK) and Hanlin L. Wang, MD, PhD56 Polycystic Liver DiseaseRomil Saxena, MBBS, MD, FRCPath (UK) and Hanlin L. Wang, MD, PhD58 Caroli DiseaseRomil Saxena, MBBS, MD, FRCPath (UK) INFECTIOUS DISORDERS 60 Overview of HepatitisNicole C. Panarelli, MD and Laura W. Lamps, MD66 Acute Viral HepatitisNicole C. Panarelli, MD and Lisa Yerian, MD70 Hepatitis BMaria Westerhoff, MD and Matthew M. Yeh, MD, PhD74 Hepatitis CMaria Westerhoff, MD and Matthew M. Yeh, MD, PhD78 Hepatitis EMaria Westerhoff, MD82 Epstein-Barr VirusLaura W. Lamps, MD, Maria Westerhoff, MD, and HanlinL. Wang, MD, PhD86 CytomegalovirusLaura W. Lamps, MD88 Herpes Simplex VirusSanjay Kakar, MD90 AdenovirusMaria Westerhoff, MD and Hanlin L. Wang, MD, PhD92 Pyogenic AbscessLaura W. Lamps, MD96 Sepsis in LiverLaura W. Lamps, MD98 Mycobacterium tuberculosisLaura W. Lamps, MD102 Atypical MycobacteriaLaura W. Lamps, MD106 Cat-Scratch DiseaseLaura W. Lamps, MD108 CandidiasisLaura W. Lamps, MD110 HistoplasmosisJoseph Misdraji, MD and Laura W. Lamps, MD114 CryptococcosisLaura W. Lamps, MD116 AmebiasisLaura W. Lamps, MD120 SchistosomiasisLaura W. Lamps, MD122 EchinococcosisLaura W. Lamps, MD CHRONIC CHOLESTATIC AND AUTOIMMUNE DISORDERS124 Autoimmune HepatitisNicole C. Panarelli, MD and Lisa Yerian, MD130 Primary Biliary CholangitisMaria Westerhoff, MD and Matthew M. Yeh, MD, PhD136 Primary Sclerosing CholangitisHanlin L. Wang, MD, PhD142 Ischemic CholangitisMaria Westerhoff, MD and Lisa Yerian, MD144 Large Bile Duct ObstructionMaria Westerhoff, MD and Laura W. Lamps, MD148 Idiopathic Adulthood DuctopeniaHanlin L. Wang, MD, PhDPEDIATRIC CHOLESTATIC DISORDERS 150 Biliary AtresiaRomil Saxena, MBBS, MD, FRCPath (UK), Grace E. Kim, MD, and Matthew M. Yeh, MD, PhD154 Idiopathic Neonatal HepatitisRomil Saxena, MBBS, MD, FRCPath (UK), Grace E. Kim, MD, and Matthew M. Yeh, MD, PhD156 Syndromic Paucity of Intrahepatic Bile Ducts(Alagille Syndrome)Joseph Misdraji, MD, Romil Saxena, MBBS, MD, FRCPath (UK), and Matthew M. Yeh, MD, PhD160 Nonsyndromic Paucity of Intrahepatic Bile DuctsRomil Saxena, MBBS, MD, FRCPath (UK), Joseph Misdraji, MD, and Matthew M. Yeh, MD, PhD DRUG/TOXIN-RELATED HEPATITIS 164 Drug-Related Acute HepatitisSanjay Kakar, MD170 Drug-Induced Acute Hepatic FailureSanjay Kakar, MD174 Drug-Induced Cholestatic Liver InjurySanjay Kakar, MD176 Drug-Related Granulomatous HepatitisLaura W. Lamps, MD180 Drug-Related Steatohepatitis/PhospholipidosisLaura W. Lamps, MD184 Reye SyndromeRomil Saxena, MBBS, MD, FRCPath (UK) and Lisa Yerian, MD186 Drug-Related Cholangitis/DuctopeniaMaria Westerhoff, MD192 Hepatic Stellate Cell HyperplasiaMaria Westerhoff, MD and Matthew M. Yeh, MD, PhD FATTY LIVER DISEASES 194 Alcoholic Liver DiseaseMaria Westerhoff, MD and Matthew M. Yeh, MD, PhD200 Nonalcoholic SteatohepatitisMaria Westerhoff, MD and Matthew M. Yeh, MD, PhD208 Glycogenic HepatopathyMaria Westerhoff, MD and Lisa Yerian, MD210 Fatty Liver of PregnancyNicole C. Panarelli, MD and Lisa Yerian, MD VASCULAR DISORDERS 212 Portal Venous ObstructionHanlin L. Wang, MD, PhD214 Hepatoportal SclerosisHanlin L. Wang, MD, PhD216 Hepatic Venous Outflow ObstructionSanjay Kakar, MD220 Venoocclusive DiseaseSanjay Kakar, MD222 AmyloidosisSanjay Kakar, MD224 Ischemia Rondell Graham, MBBS and Lisa Yerian, MD226 Nodular Regenerative HyperplasiaSanjay Kakar, MD TRANSPLANTATION PATHOLOGY 228 Ischemia Reperfusion InjuryRomil Saxena, MBBS, MD, FRCPath (UK) and Hanlin L. Wang, MD, PhD230 Antibody-Mediated RejectionHanlin L. Wang, MD, PhD and Romil Saxena, MBBS, MD, FRCPath (UK)232 T-Cell-Mediated Rejection (Acute Cellular Rejection)Romil Saxena, MBBS, MD, FRCPath (UK)236 Chronic RejectionRomil Saxena, MBBS, MD, FRCPath (UK) and Matthew M. Yeh, MD, PhD238 Central Perivenulitis/Parenchymal RejectionRondell Graham, MBBS240 Hepatic Artery ThrombosisRondell Graham, MBBS and Lisa Yerian, MD242 Graft-vs.-Host DiseaseRondell Graham, MBBS and Lisa Yerian, MD TUMORS OF THE LIVER 244 Hepatic AdenomaSanjay Kakar, MD and Matthew M. Yeh, MD, PhD252 Focal Nodular HyperplasiaSanjay Kakar, MD256 Regenerative and Dysplastic NodulesSanjay Kakar, MD262 Hepatocellular Carcinoma and VariantsSanjay Kakar, MD274 Fibrolamellar CarcinomaRondell Graham, MBBS278 Combined Hepatocellular-CholangiocarcinomaMaria Westerhoff, MD282 HepatoblastomaRondell Graham, MBBS286 Bile Duct AdenomaRondell Graham, MBBS and Sanjay Kakar, MD288 von Meyenburg Complex (Biliary Microhamartoma) Sanjay Kakar, MD, Laura W. Lamps, MD, and Rondell Graham, MBBS290 Mucinous Cystic Neoplasm, LiverMaria Westerhoff, MD and Matthew M. Yeh, MD, PhD294 Intrahepatic CholangiocarcinomaRondell Graham, MBBS and Sanjay Kakar, MD298 Intrahepatic Cholangiocarcinoma Histologic SubtypesRondell Graham, MBBS302 Intraductal Papillary NeoplasmRondell Graham, MBBS304 HemangiomaRondell Graham, MBBS306 AngiomyolipomaRondell Graham, MBBS and Lisa Yerian, MD310 Hepatic Small Vessel Neoplasm/Anastamosing HemangiomaMaria Westerhoff, MD314 Epithelioid HemangioendotheliomaSanjay Kakar, MD316 Infantile HemangiomaSanjay Kakar, MD318 AngiosarcomaSanjay Kakar, MD320 Mesenchymal HamartomaNicole C. Panarelli, MD, Hanlin L. Wang, MD, PhD, and Sanjay Kakar, MD322 Embryonal SarcomaNicole C. Panarelli, MD324 Inflammatory PseudotumorJoseph Misdraji, MD330 Segmental Atrophy (Nodular Elastosis)Joseph Misdraji, MD332 Hepatectomy Specimen HandlingRondell Graham, MBBS and Laura W. Lamps, MD MISCELLANEOUS HEPATIC DISORDERS 334 Langerhans Cell HistiocytosisMaria Westerhoff, MD and Hanlin L. Wang, MD, PhD338 Hemophagocytic SyndromesHanlin L. Wang, MD, PhD DEVELOPMENTAL/CONGENITAL 342 Congenital Pancreatic CystHanlin L. Wang, MD, PhD344 Cystic Fibrosis, PancreasHanlin L. Wang, MD, PhD346 NesidioblastosisHanlin L. Wang, MD, PhD348 Choledochal CystRomil Saxena, MBBS, MD, FRCPath (UK) and Laura W. Lamps, MD350 CholelithiasisLaura W. Lamps, MD352 Acute CholecystitisSanjay Kakar, MD354 Chronic CholecystitisSanjay Kakar, MD356 Xanthogranulomatous CholecystitisLaura W. Lamps, MD358 Eosinophilic CholecystitisLaura W. Lamps, MD360 Polyarteritis Nodosa and Other VasculitidesNicole C. Panarelli, MD362 Parasitic InfectionLaura W. Lamps, MD NONNEOPLASTIC AND INFLAMMATORY DISORDERS OF THE PANCREAS 366 Acute PancreatitisGrace E. Kim, MD and Alyssa M. Krasinskas, MD368 Chronic PancreatitisAlyssa M. Krasinskas, MD and Lisa Yerian, MD372 Autoimmune PancreatitisAlyssa M. Krasinskas, MD and Lisa Yerian, MD376 Groove PancreatitisAlyssa M. Krasinskas, MD, Lisa Yerian, MD, and Vikram Deshpande, MD378 Infectious PancreatitisLaura W. Lamps, MD380 PseudocystsAlyssa M. Krasinskas, MD, Vikram Deshpande, MD, and Lisa Yerian, MD382 Diabetes MellitusLaura W. Lamps, MD384 Lymphoepithelial Cyst of the PancreasAlyssa M. Krasinskas, MD and Lisa Yerian, MD TUMORS OF THE GALLBLADDER AND EXTRAHEPATIC BILIARY TREE386 Noninvasive Epithelial Polypoid Lesions 390 Nicole C. Panarelli, MD and Sanjay Kakar, MDCarcinoma of Gallbladder 396 Nicole C. Panarelli, MD and Laura W. Lamps, MDCarcinoma of Extrahepatic Bile Ducts 402 Rondell Graham, MBBS and Laura W. Lamps, MDSquamous/Adenosquamous Carcinoma, Gallbladder 404 Hanlin L. Wang, MD, PhDNeuroendocrine Neoplasms of Gallbladder 408 Hanlin L. Wang, MD, PhDGranular Cell Tumor 410 Nicole C. Panarelli, MDEmbryonal Rhabdomyosarcoma 412 Hanlin L. Wang, MD, PhDAdenomyoma 414 Nicole C. Panarelli, MD and Lisa Yerian, MDNonneoplastic Polypoid Gallbladder Lesions Nicole C. Panarelli, MD and Laura W. Lamps, MD TUMORS OF THE PANCREAS 418 Pancreatic Intraepithelial NeoplasiaAlyssa M. Krasinskas, MD and Sanjay Kakar, MD420 Ductal Adenocarcinoma, Including Variants Alyssa M. Krasinskas, MD, Sanjay Kakar, MD, and Mari Mino-Kenudson, MD424 Undifferentiated CarcinomaWei Zheng, MD, Sanjay Kakar, MD, and Alyssa M. Krasinskas, MD426 Adenosquamous Carcinoma, PancreasAlyssa M. Krasinskas, MD428 Serous CystadenomaSanjay Kakar, MD and Grace E. Kim, MD432 Acinar Cell CystadenomaMaria Westerhoff, MD 436 Simple Mucinous CystMaria Westerhoff, MD438 Mucinous Cystic Neoplasm, PancreasMaria Westerhoff, MD442 Intraductal Papillary Mucinous NeoplasmMari Mino-Kenudson, MD, Zaid Mahdi, MD, and Alyssa M. Krasinskas, MD448 Intraductal Oncocytic Papillary NeoplasmAlyssa M. Krasinskas, MD and Mari Mino-Kenudson, MD450 Intraductal Tubulopapillary NeoplasmAlyssa M. Krasinskas, MD and Mari Mino-Kenudson, MD452 Acinar Cell CarcinomaLaura W. Lamps, MD, Wei Zheng, MD, and Alyssa M. Krasinskas, MD456 PancreatoblastomaAlyssa M. Krasinskas, MD, Laura W. Lamps, MD, and Matthew M. Yeh, MD, PhD458 Dermoid CystZaid Mahdi, MD, Vikram Deshpande, MD, and Alyssa M. Krasinskas, MD460 Poorly Differentiated Neuroendocrine Carcinoma,PancreasSanjay Kakar, MD464 Well-Differentiated Neuroendocrine Tumor, PancreasSanjay Kakar, MD470 Solid-Pseudopapillary TumorsSanjay Kakar, MD TUMORS OF THE AMPULLA 474 Ampullary AdenomaHanlin L. Wang, MD, PhD476 Ampullary Adenocarcinoma and VariantsHanlin L. Wang, MD, PhD480 Well-Differentiated Neuroendocrine Tumor, AmpullaHanlin L. Wang, MD, PhD482 Gangliocytic ParagangliomaMaria Westerhoff, MD SPECIMEN HANDLING, WHIPPLE 484 Specimen Handling, WhippleAlyssa M. Krasinskas, MD and Laura W. Lamps, MD