000			04567cam a2200469 a 4500
001			15450351
003			ZET-ke
005			20240115113851.0
008			080915s2009 maua b 001 0 eng
010			_a 2008039921
016	7		_a101499253 _2DNLM
020			_a9780878932993 (paperbound)
020			_a0878932992 (paperbound)
035			_a(OCoLC)ocn246890208
040			_aDLC _cDLC _dZET-ke _beng
050	0	0	_aQH438.5 _b.G55 2009
060	0	0	_a2009 D-054
060	1	0	_aQU 475 _bG466e 2009
082	0	0	_a572.8/65 _222
100	1		_aGilbert, Scott F., _d1949-
245	1	0	_aEcological developmental biology : _bintegrating epigenetics, medicine, and evolution / _cScott F. Gilbert, David Epel.
260			_aSunderland, Mass. : _bSinauer Associates, _c2009.
300			_axv, 480 p. : _bill. (chiefly col.) ; _c24 cm.
504			_aIncludes bibliographical references and index.
505	0		_a1. The environment as a normal agent in producing phenotypes -- 2. How agents in the environment effect molecular changes in development -- 3. Developmental symbiosis: co-development as a strategy for life -- 4. Embryonic defenses: survival in a hostile world -- 5. Teratogenesis: environmental assaults on development -- 6. Endocrine disruptors -- 7. The epigenetic origin of adult diseases -- 8. The modern synthesis: natural selection of allelic variation -- 9. Evolution through developmental regulatory genes -- 10. Environment, development, and evolution: toward a new synthesis -- Coda: philosophical concerns raised by ecological developmental biology.
520			_a"When the molecular processes of epigenetics meet the ecological processes of phenotypic plasticity, the result is a revolutionary new field: ecological developmental biology, or "eco-devo." This new science studies development in the "real world" of predators, pathogens, competitors, symbionts, toxic compounds, temperature changes, and nutritional differences. These environmental agents can result in changes to an individual's phenotype, often implemented when signals from the environment elicit epigenetic changes in gene expression. Ecological developmental biology is a truly integrative biology, detailing the interactions between developing organisms and their environmental contexts. Ecological developmental biology also provides a systems approach to the study of pathology, integrating the studies of diabetes, cancers, obesity, and the aging syndrome into the framework of an ecologically sensitive developmental biology. It looks at examples where the environment provides expected cues for normal development and where the organism develops improperly without such cues. Data from research on teratology, endocrine disruptors, and microbial symbioses, when integrated into a developmental context, may have enormous implications for human health as well as the overall health of Earth's ecosystems. The study of epigenetics--changes in gene expression that are not the result of changes in a gene's DNA sequence--has recently provided startling insights not only into mechanisms of development, but also into the mechanisms and processes of evolution. The notion that epialleles (changes in chromosome structure that alter gene expression) can be induced by environmental agents and transmitted across generations has altered our notions of evolution, as have new experiments documenting the genetic fixation of environmentally induced changes in development. The widespread use of symbiosis in development provides new targets for natural selection. Ecological developmental biology integrates these new ideas into an extended evolutionary synthesis that retains and enriches the notion of evolution by natural selection."--Publisher's description.
650		0	_aPhenotypic plasticity.
650		0	_aDevelopmental biology.
650		0	_aEpigenesis.
650		0	_aEvolution (Biology)
650	1	2	_aEpigenesis, Genetic.
650	2	2	_aAdaptation, Biological _xgenetics.
650	2	2	_aEndocrine Disruptors _xadverse effects.
650	2	2	_aEnvironmental Pollution _xadverse effects.
650	2	2	_aGene Expression Regulation, Developmental _xphysiology.
650	2	2	_aTeratogens.
700	1		_aEpel, David.
856	4	1	_3Table of contents only _uhttp://www.loc.gov/catdir/toc/ecip0828/2008039921.html
906			_a7 _bcbc _corignew _d1 _eecip _f20 _gy-gencatlg
942			_2lcc _cBK _hQH438.5 _kQH438.5 _m.G55 2009
999			_c5617 _d5617