HMGB1 : functions, inhibitors and clinical significance /
HMGB1 : functions, inhibitors and clinical significance /
Eylem Taskin, PhD (editor), Professor, Physiology, Adiyaman University, Adiyaman, Turkey, Celal Guven, PhD (editor), Associate Professor, Biophysics, Adiyaman University, Adiyaman, Turkey, Salih Tunc Kaya, PhD (editor), Assistant Dr., Biology, Duzce University, Duzce, Turkey.
- 1 online resource.
- Life sciences research and development .
Includes bibliographical references and index.
"High mobility group box-1 (HMGB1) is one of the Damage-associated molecular patterns (DAMPs). HMGB1 plays plenty of role in both physiologic and pathophysiologic processes associated with its location, the receptor it binds to, and its redox form of its. Its functions are basically well known to have transcription factors, chemo-attractive effects, proinflammatory cytokine, neither chemokine nor cytokine effects, nor tissue repair function as well. This book provides an overview of the updated understanding of the dual role of HMGB1 in health and disease, such as cancer, myocardial ischemia/reperfusion injury, epilepsy, diabetes, multiple sclerosis, and neurodegenerative disease as well as hepatic steatosis and fatty liver disease been studied for years. That is why the modulation of HMGB1 might be a good candidate for the therapeutic of these diseases. Consequently, the present book comprises the role of HMGB1 in various pathologies and discusses its therapeutic potential in those pathologies"--
8886974661 9788886974660 8886974663 9798886974669
2022054766
Chromatin--Miscellanea.
Nervous system--Diseases--Pathophysiology.
Chromatine--Miscellan�ees.
Syst�eme nerveux--Maladies.
QH599
572.8/7
Includes bibliographical references and index.
"High mobility group box-1 (HMGB1) is one of the Damage-associated molecular patterns (DAMPs). HMGB1 plays plenty of role in both physiologic and pathophysiologic processes associated with its location, the receptor it binds to, and its redox form of its. Its functions are basically well known to have transcription factors, chemo-attractive effects, proinflammatory cytokine, neither chemokine nor cytokine effects, nor tissue repair function as well. This book provides an overview of the updated understanding of the dual role of HMGB1 in health and disease, such as cancer, myocardial ischemia/reperfusion injury, epilepsy, diabetes, multiple sclerosis, and neurodegenerative disease as well as hepatic steatosis and fatty liver disease been studied for years. That is why the modulation of HMGB1 might be a good candidate for the therapeutic of these diseases. Consequently, the present book comprises the role of HMGB1 in various pathologies and discusses its therapeutic potential in those pathologies"--
8886974661 9788886974660 8886974663 9798886974669
2022054766
Chromatin--Miscellanea.
Nervous system--Diseases--Pathophysiology.
Chromatine--Miscellan�ees.
Syst�eme nerveux--Maladies.
QH599
572.8/7